Multi-modal single-cell sequencing enables mapping of mutant and wild-type human hematopoietic stem and progenitor cells within the same person, to define cellular phenotypic and epigenetic perturbations associated with clonal hematopoiesis.
This is a preview of subscription content, access via your institution
Subscribe to Nature+
Get immediate online access to Nature and 55 other Nature journal
Subscribe to Journal
Get full journal access for 1 year
only $6.58 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Get time limited or full article access on ReadCube.
All prices are NET prices.
Mustjoki, S. & Young, N. S. Somatic mutations in ‘benign’ disease. N. Engl. J. Med. 384, 2039–2052 (2021). This review article presents the current understanding of somatic mosaicism and its effects on human disease.
Jaiswal, S. et al. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371, 2488–2498 (2014). This paper reports the high prevalence of CH and the associated increased risk of developing hematopoietic malignancies.
Nam, A. S. et al. Somatic mutations and cell identity linked by genotyping of transcriptomes. Nature 571, 355–360 (2019). This article reports the development of single-cell multi-omics that capture the mutational status and whole transcriptomes of hematopoietic stem progenitor cells.
Gaiti, F. et al. Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia. Nature 569, 576–580 (2019). This paper presents multi-modality single-cell sequencing that enables single-cell lineage tracing, linked with transcriptional and mutational status.
Nam, A. S. et al. Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics. Nat. Rev. Genet. 22, 3–18 (2021). This review article presents the role of single-cell multi-omics in delineating the clonal evolution of human cancer by integrating genetic, cell state, epigenetic, and micro-environmental factors that enable fitness.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Nam, A. S. et al. Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation. Nat. Genet. https://doi.org/10.1038/s41588-022-01179-9 (2022).
About this article
Cite this article
Somatic mosaicism rewires transcriptional and epigenetic states in clonal hematopoiesis. Nat Genet 54, 1453–1454 (2022). https://doi.org/10.1038/s41588-022-01181-1