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Transitioning cancer cells and the surrounding tumor environment in pancreatic cancer

In our study of 83 tissue samples from 31 patients with pancreatic cancer receiving different treatment regimens, we directly identified normal cells transitioning to a tumor state. Single-cell technologies enabled us to observe how the tumor and the surrounding environment work together to create a treatment-resistant niche.

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Fig. 1: The cellular origin of pancreatic cancer development.


  1. The Cancer Genome Atlas Research Network. Integrated genomic characterization of pancreatic ductal adenocarcinoma. Cancer Cell 32, 185–203 (2017). This paper reports the genomic, transcriptomic and proteomic profiling of 150 patients with pancreatic cancer.

    Article  Google Scholar 

  2. Cao, L., Huang, C. & Zhou, D. C. Proteogenomic characterization of pancreatic ductal adenocarcinoma. Cell 184, 5031–5052 (2021). This paper reports multi-omics integration of pancreatic samples, with a focus on the tumor proteome.

    Article  CAS  Google Scholar 

  3. Human Tumor Atlas Network. The Human Tumor Atlas Network: charting tumor transitions across space and time at single-cell resolution. Cell 181, 236–249 (2020). This paper reports the goals of the National Cancer Institute Initiative Human Tumor Atlas Network.

    Article  Google Scholar 

  4. Zheng, G., Terry, J. & Belgrader, P. et al. Massively parallel digital transcriptional profiling of single cells. Nat Commun 8, 14049 (2017). This paper reports the process of single-cell RNA sequencing by 10X genomics.

    Article  CAS  Google Scholar 

  5. Storz, P. Acinar cell plasticity and development of pancreatic ductal adenocarcinoma. Nat. Rev. Gastroenterol. Hepatol. 14, 296–304 (2017). This Review article summarizes acinar cells and tumor cell development in pancreatic cancer.

    Article  CAS  Google Scholar 

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This is a summary of: Cui Zhou, D. et al. Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat. Genet. (2022).

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Transitioning cancer cells and the surrounding tumor environment in pancreatic cancer. Nat Genet 54, 1269–1270 (2022).

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