In our study of 83 tissue samples from 31 patients with pancreatic cancer receiving different treatment regimens, we directly identified normal cells transitioning to a tumor state. Single-cell technologies enabled us to observe how the tumor and the surrounding environment work together to create a treatment-resistant niche.
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This is a summary of: Cui Zhou, D. et al. Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat. Genet. https://doi.org/10.1038/s41588-022-01157-1 (2022).
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Transitioning cancer cells and the surrounding tumor environment in pancreatic cancer. Nat Genet 54, 1269–1270 (2022). https://doi.org/10.1038/s41588-022-01162-4
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DOI: https://doi.org/10.1038/s41588-022-01162-4
