We generated a cattle genotype–tissue expression atlas (CattleGTEx) as part of the farm animal GTEx project. Analysis of 7,180 public RNA-sequencing samples revealed genetic variants that regulate the transcriptome across 23 distinct bovine tissues. Integrating these data with GWAS advances our understanding of the fundamental molecular mechanisms that underpin complex traits in cattle.
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Hu, Z. L., Park, C. A. & Reecy, J. M. Bringing the Animal QTLdb and CorrDB into the future: meeting new challenges and providing updated services. Nucleic Acids Res. 50, D956–D961 (2022). This paper reports the latest update of quantitative trait loci in the livestock genome research community.
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This is a summary of: Liu, S. et al. A multi-tissue atlas of regulatory variants in cattle. Nat. Genet. https://doi.org/10.1038/s41588-022-01153-5 (2022).
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The CattleGTEx atlas reveals regulatory mechanisms underlying complex traits. Nat Genet 54, 1273–1274 (2022). https://doi.org/10.1038/s41588-022-01155-3