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PAN-CANCER GENOMICS

Mapping the cancer cell states conserved across solid tumors

Nature Genetics volume 54, pages 1066–1067 (2022)Cite this article

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A new study uses single-cell and spatial transcriptomics to provide a systematic characterization of the recurrent gene-expression programs that control neoplastic cell states in diverse cancers.

Cancer cells must acquire a diversity of traits to thrive in a challenging environment, but the molecular programs that coordinate these traits are incompletely understood. A new study provides a systematic characterization of the recurrent gene-expression programs that control these traits in neoplastic cells from diverse cancers at single-cell, and spatial, resolution.

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Fig. 1: Distinct combinations of gene modules can be adopted by cancer cells in the tumor microenvironment.

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Authors and Affiliations

  1. Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

    Daniel Roden & Alexander Swarbrick

  2. School of Clinical Medicine, Faculty of Medicine, UNSW Sydney, Sydney, New South Wales, Australia

    Daniel Roden & Alexander Swarbrick

Authors
  1. Daniel Roden
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  2. Alexander Swarbrick
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Correspondence to Alexander Swarbrick.

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The authors declare no competing interests.

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Roden, D., Swarbrick, A. Mapping the cancer cell states conserved across solid tumors. Nat Genet 54, 1066–1067 (2022). https://doi.org/10.1038/s41588-022-01151-7

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  • DOI: https://doi.org/10.1038/s41588-022-01151-7

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