Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

PAN-CANCER GENOMICS

Mapping the cancer cell states conserved across solid tumors

A new study uses single-cell and spatial transcriptomics to provide a systematic characterization of the recurrent gene-expression programs that control neoplastic cell states in diverse cancers.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Distinct combinations of gene modules can be adopted by cancer cells in the tumor microenvironment.

References

  1. Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).

    CAS  PubMed  Google Scholar 

  2. Barkley, D. et al. Nat. Genet. https://doi.org/10.1038/s41588-022-01141-9 (2022).

    Article  Google Scholar 

  3. Neftel, C. et al. Cell 178, 835–849.e2 (2019).

    Article  CAS  Google Scholar 

  4. Puram, S. V. et al. Cell 171, 1611–1624.e24 (2017).

    Article  CAS  Google Scholar 

  5. Wu, S. Z. et al. Nat. Genet. 53, 1334–1347 (2021).

    Article  CAS  Google Scholar 

  6. Jackson, H. W. et al. Nature 578, 615–620 (2020).

    Article  CAS  Google Scholar 

  7. Kinker, G. S. et al. Nat. Genet. 52, 1208–1218 (2020).

    Article  CAS  Google Scholar 

  8. Cheng, S. et al. Cell 184, 792–809.e23 (2021).

    Article  CAS  Google Scholar 

  9. Goltsev, Y. et al. Cell 174, 968–981.e15 (2018).

    Article  CAS  Google Scholar 

  10. Perou, C. M. et al. Nature 406, 747–752 (2000).

    Article  CAS  Google Scholar 

  11. Network, T. C. G. A. R. Cell 163, 1011–1025 (2015).

    Article  Google Scholar 

  12. Cook, D. P. & Vanderhyden, B. C. Nat. Commun. 11, 2142 (2020).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alexander Swarbrick.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Roden, D., Swarbrick, A. Mapping the cancer cell states conserved across solid tumors. Nat Genet 54, 1066–1067 (2022). https://doi.org/10.1038/s41588-022-01151-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-022-01151-7

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer