In the zebrafish heart, several transient fibroblast types appear after injury. High-throughput lineage tracing revealed that injury-responsive fibroblasts are derived from two distinct lineage origins: the epicardium and the endocardium. Targeted cell-type-specific depletion showed that at least one fibroblast type has a critical role in heart regeneration.
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This is a summary of: Hu, B. et al. Origin and function of activated fibroblast states during zebrafish heart regeneration. Nat. Genet. https://doi.org/10.1038/s41588-022-01129-5 (2022).
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Transient activated fibroblasts contribute to zebrafish heart regeneration. Nat Genet 54, 1076–1077 (2022). https://doi.org/10.1038/s41588-022-01130-y