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Identification of two intrinsic epithelial subtypes of colorectal cancer

By integrating single-cell and bulk transcriptomic analyses, we found that malignant cells belong to two major intrinsic epithelial subtypes. We propose a refined, three-tiered classification of colorectal cancer subtypes based on intrinsic epithelial subtypes, microsatellite instability status and the presence of fibrosis.

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Fig. 1: Proposed IMF classification of CRC.

References

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This is a summary of: Joanito, I. et al. Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer. Nat. Genet. https://doi.org/10.1038/s41588-022-01100-4 (2022).

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Identification of two intrinsic epithelial subtypes of colorectal cancer. Nat Genet 54, 924–925 (2022). https://doi.org/10.1038/s41588-022-01101-3

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