By integrating single-cell and bulk transcriptomic analyses, we found that malignant cells belong to two major intrinsic epithelial subtypes. We propose a refined, three-tiered classification of colorectal cancer subtypes based on intrinsic epithelial subtypes, microsatellite instability status and the presence of fibrosis.
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References
Guinney, J. et al. The consensus molecular subtypes of colorectal cancer. Nat. Med. 21, 1350–1356 (2015). This paper is an international consensus effort leading to the four consensus molecular subtypes of CRC based on bulk gene expression classifiers.
Bramsen, J. B. et al. Molecular-subtype-specific biomarkers improve prediction of prognosis in colorectal cancer. Cell Rep. 19, 1268–1280 (2017). This article uses deconvolution of bulk expression as a computational estimate of subtype-specific biomarkers for CRC prognostication.
Peng, X. L., Moffitt, R. A., Torphy, R. J., Volmar, K. E. & Yeh, J. J. De novo compartment deconvolution and weight estimation of tumor samples using DECODER. Nat. Commun. 10, 4729 (2019). This paper presents a deconvolution method for cell type expression and abundance from bulk expression profiles.
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This is a summary of: Joanito, I. et al. Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer. Nat. Genet. https://doi.org/10.1038/s41588-022-01100-4 (2022).
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Identification of two intrinsic epithelial subtypes of colorectal cancer. Nat Genet 54, 924–925 (2022). https://doi.org/10.1038/s41588-022-01101-3
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DOI: https://doi.org/10.1038/s41588-022-01101-3
