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PLANT GENOMICS

Graph pangenomes find missing heritability

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The use of association studies to identify candidate genes for complex biological traits in plants has been challenging due to a reliance on single reference genomes, leading to missing heritability. Graphical pangenomes and the identification of causal variants help overcome this and provide an important advance for crop breeding.

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Fig. 1: Graph pangenomes capture the genomic diversity that underlies the observed phenotypic diversity and maintains this structural variation information within the context of linear chromosomes.

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Correspondence to David Edwards or Jacqueline Batley.

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The authors declare no competing interests.

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Edwards, D., Batley, J. Graph pangenomes find missing heritability. Nat Genet 54, 919–920 (2022). https://doi.org/10.1038/s41588-022-01099-8

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  • DOI: https://doi.org/10.1038/s41588-022-01099-8

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