Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


One step closer to linking GWAS SNPs with the right genes

A new study highlights a strategy to link SNPs implicated in human complex traits and diseases with probable causal genes. This method prioritizes genes for functional characterization and helps address questions about the architecture of human phenotypes.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Necessary steps to understand how GWAS discoveries impact human health and disease.


  1. Buniello, A. et al. Nucleic Acids Res. 47, D1005–D1012 (2019).

    CAS  Article  Google Scholar 

  2. Gazal, S. et al. Nat. Genet. (2022).

    Article  PubMed  Google Scholar 

  3. Finucane, H. K. et al. Nat. Genet. 47, 1228–1235 (2015).

    CAS  Article  Google Scholar 

  4. Mountjoy, E. et al. Nat. Genet. 53, 1527–1533 (2021).

    CAS  Article  Google Scholar 

  5. Weissbrod, O. et al. Nat. Genet. 52, 1355–1363 (2020).

    CAS  Article  Google Scholar 

  6. Boyle, E. A., Li, Y. I. & Pritchard, J. K. Cell 169, 1177–1186 (2017).

    CAS  Article  Google Scholar 

  7. Wray, N. R., Wijmenga, C., Sullivan, P. F., Yang, J. & Visscher, P. M. Cell 173, 1573–1580 (2018).

    CAS  Article  Google Scholar 

  8. Backman, J. D. et al. Nature 599, 628–634 (2021).

    CAS  Article  Google Scholar 

  9. Nasser, J. et al. Nature 593, 238–243 (2021).

    CAS  Article  Google Scholar 

  10. Abell, N. S. et al. Science 375, 1247–1254 (2022).

    CAS  Article  Google Scholar 

  11. Perez, R. K. et al. Science 376, eabf1970 (2022).

    CAS  Article  Google Scholar 

  12. Yazar, S. et al. Science 376, eabf3041 (2022).

    CAS  Article  Google Scholar 

  13. Musunuru, K. et al. Nature 466, 714–719 (2010).

    CAS  Article  Google Scholar 

  14. Bauer, D. E. et al. Science 342, 253–257 (2013).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Guillaume Lettre.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Lettre, G. One step closer to linking GWAS SNPs with the right genes. Nat Genet 54, 748–749 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing