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Polygenic risk scores for CARDINAL study

The Cardiometabolic Disorders in African-Ancestry Populations (CARDINAL) study site is a well-powered, first-of-its-kind resource for developing, refining and validating methods for research into polygenic risk scores that accounts for local ancestry, to improve risk prediction in diverse populations.

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Fig. 1: Ancestry distribution in GWAS.
Fig. 2: Geographic representation of the core cohorts.

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Acknowledgements

CARDINAL is funded by the Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry – Study Sites (NIH/NHGRI 1U01HG011717). We are very grateful to the individuals who participated in the studies included in the CARDINAL study site and members of the research groups that contributed to each study. We are also grateful for the following projects funded by the National Institutes of Health (NIH): African Collaborative Center for Microbiome and Genomics Research Grant (NIH/NHGRI 1U54HG006947), AWI-Gen Collaborative Centre (NIH/NHGRI U54HG006938); Eyes of Africa: The Genetics of Blindness (NIH/NHGRI and NEI, U54HG009826); and SIREN (U54HG007479). T.C. is an international training fellow supported by the Wellcome Trust grant (214205/Z/18/Z). S.F. is an international Intermediate Fellow funded by the Wellcome Trust grant (220740/Z/20/Z) at the MRC/UVRI and LSHTM

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S.N.A. drafted the manuscript, created the figures and tables. All authors reviewed the manuscript and approved the final version.

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Correspondence to Sally N. Adebamowo.

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The authors declare no conflict of interest. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscripts.

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Adebamowo, C.A., Adeyemo, A., Ashaye, A. et al. Polygenic risk scores for CARDINAL study. Nat Genet 54, 527–530 (2022). https://doi.org/10.1038/s41588-022-01074-3

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