A new study demonstrates that the disordered N-terminal domain of DNMT3A1 binds PRC1-catalyzed H2AK119ub, targeting DNA methylation to bivalent promoters in mouse brain cortical cells. Methylation around bivalent genes is critical for mouse postnatal development, and could be equally important in other cell types and in disease.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Li, E. & Zhang, Y. Cold Spring Harb. Perspect. Biol. 6, a019133 (2014).
Okano, M., Bell, D. W., Haber, D. A. & Li, E. Cell 99, 247–257 (1999).
Remacha, L. et al. Genet. Med. Off. J. Am. Coll. Med. Genet. 20, 1644–1651 (2018).
Heyn, P. et al. Nat. Genet. 51, 96–105 (2019).
Yang, L., Rau, R. & Goodell, M. A. Nat. Rev. Cancer 15, 152–165 (2015).
Otani, J. et al. EMBO Rep. 10, 1235–1241 (2009).
Dhayalan, A. et al. J. Biol. Chem. 285, 26114–26120 (2010).
Gu, T. et al. Nat. Genet. https://doi.org/10.1038/s41588-022-01063-6 (2022).
Bernstein, B. E. et al. Cell 125, 315–326 (2006).
Azuara, V. et al. Nat. Cell Biol. 8, 532–538 (2006).
Johnson, K. C. et al. Nat. Commun. 7, 13177 (2016).
Verma, N. et al. Nat. Genet. 50, 83–95 (2018).
Bachman, M. et al. Nat. Chem. 6, 1049–1055 (2014).
Reddington, J. P. et al. Genome Biol. 14, R25 (2013).
Weinberg, D. N. et al. Nat. Genet. 53, 794–800 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
W.R. is a consultant and shareholder of Cambridge Epigenetix. W.R. is employed by Altos Labs. The remaining authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Parry, A.J., Reik, W. DNMT3A binds ubiquitinated histones to regulate bivalent genes. Nat Genet 54, 537–538 (2022). https://doi.org/10.1038/s41588-022-01073-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-022-01073-4
