A study using single-cell transcriptomics and mapping of expression quantitative trait loci (eQTLs) in a dynamic model of CD4+ T cell activation reveals novel, context-specific eQTLs linked to genes associated with immune diseases such as inflammatory bowel disease.
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Cano-Gamez, E. et al. Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines. Nat. Commun. 11, 1801 (2020). Though the use of single-cell transcriptomics, this work demonstrated that T cells form a continuum of cell types and states.
Soskic, B. et al. Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases. Nat. Genet. 51, 1486–1493 (2019). This work showed that immune-disease variants undergo enrichment for active chromatin regions that are upregulated after T cell activation.
Fang, H. et al. A genetics-led approach defines the drug target landscape of 30 immune-related traits. Nat. Genet. 51, 1082–1091 (2019). This work used a genetics-led approach to identify known drug targets for immune traits and nominate new ones.
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This is a summary of: Soskic, B. et al. Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation. Nat. Genet. https://doi.org/10.1038/s41588-022-01066-3 (2022).
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A molecular map of T cell activation gives insights into immune disease. Nat Genet 54, 752–753 (2022). https://doi.org/10.1038/s41588-022-01067-2