Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A molecular map of T cell activation gives insights into immune disease

    Nature Genetics volume 54, pages 752–753 (2022)Cite this article

    Subjects

    A study using single-cell transcriptomics and mapping of expression quantitative trait loci (eQTLs) in a dynamic model of CD4+ T cell activation reveals novel, context-specific eQTLs linked to genes associated with immune diseases such as inflammatory bowel disease.

    Your institute does not have access to this article

    Access options

    Buy article

    Get time limited or full article access on ReadCube.

    $32.00

    Buy

    All prices are NET prices.

    Fig. 1: Dynamic eQTL mapping in activated T cells.

    References

    1. Cano-Gamez, E. et al. Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines. Nat. Commun. 11, 1801 (2020). Though the use of single-cell transcriptomics, this work demonstrated that T cells form a continuum of cell types and states.

      CAS  Article  Google Scholar 

    2. Soskic, B. et al. Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases. Nat. Genet. 51, 1486–1493 (2019). This work showed that immune-disease variants undergo enrichment for active chromatin regions that are upregulated after T cell activation.

      CAS  Article  Google Scholar 

    3. Fang, H. et al. A genetics-led approach defines the drug target landscape of 30 immune-related traits. Nat. Genet. 51, 1082–1091 (2019). This work used a genetics-led approach to identify known drug targets for immune traits and nominate new ones.

      CAS  Article  Google Scholar 

    Download references

    Additional information

    Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

    This is a summary of: Soskic, B. et al. Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation. Nat. Genet. https://doi.org/10.1038/s41588-022-01066-3 (2022).

    Rights and permissions

    Reprints and Permissions

    About this article

    Verify currency and authenticity via CrossMark

    Cite this article

    A molecular map of T cell activation gives insights into immune disease. Nat Genet 54, 752–753 (2022). https://doi.org/10.1038/s41588-022-01067-2

    Download citation

    • Published:

    • Issue Date:

    • DOI: https://doi.org/10.1038/s41588-022-01067-2

    Search

    Advanced search

    Quick links

    Nature Briefing

    Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

    Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing