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3D GENOMICS

BET proteins loop and compartmentalize the 3D genome

Nature Genetics volume 54, pages 370–371 (2022)Cite this article

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Chromosomes are shaped by an interplay between loop extrusion and compartmentalization. Two new studies demonstrate that bromodomain and extraterminal domain (BET) proteins contribute to both processes, with BRD4 facilitating one process and surprisingly inhibiting the other.

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Fig. 1: Dual roles of BRD4 in genome organization.

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Acknowledgements

K.P.E. is grateful to B. Di Stefano, R. J. Parchem and M. L. K. Williams for critical reading of the manuscript and apologizes to those whose work could not be cited due to space limitations. Research in the Eagen laboratory is supported by an NIH Director’s Early Independence Award (DP5OD024587) and a Cancer Prevention & Research Institute of Texas Recruitment of First-Time, Tenure-Track Faculty Member Award (RR210082).

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Authors and Affiliations

  1. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

    Kyle P. Eagen

  2. Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA

    Kyle P. Eagen

  3. Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA

    Kyle P. Eagen

  4. Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA

    Kyle P. Eagen

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  1. Kyle P. Eagen
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Correspondence to Kyle P. Eagen.

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Eagen, K.P. BET proteins loop and compartmentalize the 3D genome. Nat Genet 54, 370–371 (2022). https://doi.org/10.1038/s41588-022-01031-0

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