A large-scale single-nucleus chromatin accessibility profiling study in coronary artery samples from patients with coronary artery disease generated a landscape of the regulatory activity during the disease. These data highlight cell type-specific gene programs that can improve the interpretation of human genome-wide association studies findings for cardiovascular diseases.
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References
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This is a summary of: Turner, A. W. et al. Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk. Nat. Genet. https://doi.org/10.1038/s41588-022-01069-0 (2022).
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Chromatin profiling of coronary artery illuminates genetic risk for heart disease. Nat Genet 54, 750–751 (2022). https://doi.org/10.1038/s41588-022-01029-8
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DOI: https://doi.org/10.1038/s41588-022-01029-8
