Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Nascent transcription as a predictor and driver of histone modifications

A new study demonstrates that profiles of nascent RNA accurately predict genomic patterns of histone modifications and chromatin state. Consistent with that, active histone marks are revealed to reflect transcription activity, rather than preceding or directing gene output.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: RNA polymerase activity directs the deposition and maintenance of histone modifications.


  1. Barski, A. et al. Cell 129, 823–837 (2007).

    Article  CAS  Google Scholar 

  2. Heintzman, N. D. et al. Nat. Genet. 39, 311–318 (2007).

    Article  CAS  Google Scholar 

  3. Ernst, J. & Kellis, M. Nat. Methods 9, 215–216 (2012).

    Article  CAS  Google Scholar 

  4. Kwasnieski, J. C., Fiore, C., Chaudhari, H. G. & Cohen, B. A. Genome Res. 24, 1595–1602 (2014).

    Article  CAS  Google Scholar 

  5. Fulco, C. P. et al. Nat. Genet. 51, 1664–1669 (2019).

    Article  CAS  Google Scholar 

  6. Wang, Z. et al. Nat. Genet. (2022).

  7. Kwak, H., Fuda, N. J., Core, L. J. & Lis, J. T. Science 339, 950–953 (2013).

    Article  CAS  Google Scholar 

  8. Core, L. J. et al. Nat. Genet. 46, 1311–1320 (2014).

    Article  CAS  Google Scholar 

  9. Wang, Z., Chu, T., Choate, L. A. & Danko, C. G. Genome Res. 29, 293–303 (2019).

    Article  CAS  Google Scholar 

  10. Henriques, T. et al. Genes Dev. 32, 26–41 (2018).

    Article  CAS  Google Scholar 

  11. Chu, T. et al. Nat. Genet. 50, 1553–1564 (2018).

    Article  CAS  Google Scholar 

  12. Dorighi, K. M. et al. Mol. Cell 66, 568–576.e4 (2017).

    Article  CAS  Google Scholar 

  13. Rickels, R. et al. Nat. Genet. 49, 1647–1653 (2017).

    Article  CAS  Google Scholar 

  14. Martin, B. J. E. et al. Nat. Commun. 12, 210 (2021).

    Article  CAS  Google Scholar 

  15. Long, Y. et al. Nat. Genet. 52, 931–938 (2020).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Karen Adelman.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Adelman, K. Nascent transcription as a predictor and driver of histone modifications. Nat Genet 54, 223–224 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing