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Nascent transcription as a predictor and driver of histone modifications

A new study demonstrates that profiles of nascent RNA accurately predict genomic patterns of histone modifications and chromatin state. Consistent with that, active histone marks are revealed to reflect transcription activity, rather than preceding or directing gene output.

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Fig. 1: RNA polymerase activity directs the deposition and maintenance of histone modifications.

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Correspondence to Karen Adelman.

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Adelman, K. Nascent transcription as a predictor and driver of histone modifications. Nat Genet 54, 223–224 (2022). https://doi.org/10.1038/s41588-021-01004-9

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