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Nascent transcription as a predictor and driver of histone modifications

Nature Genetics volume 54, pages 223–224 (2022)Cite this article

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A new study demonstrates that profiles of nascent RNA accurately predict genomic patterns of histone modifications and chromatin state. Consistent with that, active histone marks are revealed to reflect transcription activity, rather than preceding or directing gene output.

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Fig. 1: RNA polymerase activity directs the deposition and maintenance of histone modifications.

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  1. Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA

    Karen Adelman

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  1. Karen Adelman
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Correspondence to Karen Adelman.

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The author declares no competing interests.

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Adelman, K. Nascent transcription as a predictor and driver of histone modifications. Nat Genet 54, 223–224 (2022). https://doi.org/10.1038/s41588-021-01004-9

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