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The regulatory network architecture of cardiometabolic diseases

Complex disease definitions often represent descriptive umbrella terms of symptoms rather than mechanistic entities. A new study shows how network-based approaches can help identify the mechanisms that link genes, cells, tissues and organs in cardiovascular diseases.

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Fig. 1: A mechanistic understanding of complex diseases requires a detailed mapping of the underlying perturbations across biological networks.

FrankRamspott / DigitalVision Vectors / Getty (proteome graphic); sumkinn / iStock / Getty Images Plus/Getty (transcriptome graphic)


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Correspondence to Harald H. H. W. Schmidt or Jörg Menche.

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The authors declare no competing interests.

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Schmidt, H.H.H.W., Menche, J. The regulatory network architecture of cardiometabolic diseases. Nat Genet 54, 2–3 (2022).

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