Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

ONCOGENE AMPLIFICATION

Decoding complex patterns of oncogene amplification

Oncogene amplification is a major driver of tumorigenesis; yet, the mechanisms generating amplification are only partially understood. New research reports on the identification of a new focal amplification pattern termed ‘seismic amplification’ that is hypothesized to originate from recombination between extrachromosomal DNA circles.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Mechanisms for oncogene amplification.

References

  1. 1.

    Li, Y. et al. Nature 578, 112–121 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Stephens, P. J. et al. Cell 144, 27–40 (2011).

    CAS  Article  Google Scholar 

  3. 3.

    Zhang, C. Z. et al. Nature 522, 179–184 (2015).

    CAS  Article  Google Scholar 

  4. 4.

    Maciejowski, J. et al. Cell 163, 1641–1654 (2015).

    CAS  Article  Google Scholar 

  5. 5.

    Umbreit, N. T. et al. Science 368, eaba0712 (2020).

    CAS  Article  Google Scholar 

  6. 6.

    Shoshani, O. et al. Nature 591, 137–141 (2021).

    CAS  Article  Google Scholar 

  7. 7.

    Rosswog, C. et al. Nat. Genet. https://doi.org/10.1038/s41588-021-00951-7 (2021).

  8. 8.

    Tanaka, H. & Watanabe, T. Trends Cancer 6, 462–477 (2020).

    CAS  Article  Google Scholar 

  9. 9.

    Rausch, T. et al. Cell 148, 59–71 (2012).

    CAS  Article  Google Scholar 

  10. 10.

    Cowell, J. K. & Miller, O. J. Chromosoma 88, 216–221 (1983).

    CAS  Article  Google Scholar 

  11. 11.

    McClintock, B. Cold Spring Harb. Symp. Quant. Biol. 9, 72–81 (1941).

    Article  Google Scholar 

  12. 12.

    Bignell, G. R. et al. Genome Res. 17, 1296–1303 (2007).

    CAS  Article  Google Scholar 

  13. 13.

    Hadi, K. et al. Cell 183, 197–210 (2020).

    CAS  Article  Google Scholar 

  14. 14.

    Garsed, D. W. et al. Cancer Cell 26, 653–667 (2014).

    CAS  Article  Google Scholar 

  15. 15.

    Shimizu, N. Mutagenesis 26, 119–123 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to David Pellman.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Pellman, D., Zhang, CZ. Decoding complex patterns of oncogene amplification. Nat Genet (2021). https://doi.org/10.1038/s41588-021-00974-0

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing