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Decoding complex patterns of oncogene amplification

Oncogene amplification is a major driver of tumorigenesis; yet, the mechanisms generating amplification are only partially understood. New research reports on the identification of a new focal amplification pattern termed ‘seismic amplification’ that is hypothesized to originate from recombination between extrachromosomal DNA circles.

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Fig. 1: Mechanisms for oncogene amplification.


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Correspondence to David Pellman.

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Pellman, D., Zhang, CZ. Decoding complex patterns of oncogene amplification. Nat Genet 53, 1626–1627 (2021).

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