How somatic and germline mutations interact in cancer remains largely unexplored. A study of 17,152 patients with cancer suggests that the relative contribution of pathogenic germline mutations is governed by lineage and penetrance.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Broca P. Traité de Tumeurs (P. Asselin, 1866).
Sondka, Z. et al. Nat. Rev. Cancer 18, 696–705 (2018).
Alexandrov, L. B. et al. Nature 500, 415–421 (2013).
Knudson, A. G. Proc. Natl Acad. Sci. USA 68, 820–823 (1971).
Rahman, N. Nature 505, 302–308 (2014).
Park, S. L. et al. Cancer Epidemiol. Biomarkers Prev. 27, 405–417 (2018).
Srinivasan, P. et al. Nat. Genet. https://doi.org/10.1038/s41588-021-00949-1 (2021).
Huang, K.-l et al. Cell 173, 355–370 (2018).
Tavtigian, S. et al. Hum. Mutat. 29, 1261–1264 (2008).
De Andrade, K. et al. Hum. Mutat. 40, 97–105 (2019).
Moore, L. et al. Nature 597, 381–386 (2021).
Wilkinson, M. D. et al. Sci. Data 6, 174 (2016).
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Chanock, S.J. How the germline informs the somatic landscape. Nat Genet 53, 1523–1525 (2021). https://doi.org/10.1038/s41588-021-00960-6