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GERMLINE MUTATIONS

How the germline informs the somatic landscape

Nature Genetics volume 53, pages 1523–1525 (2021)Cite this article

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How somatic and germline mutations interact in cancer remains largely unexplored. A study of 17,152 patients with cancer suggests that the relative contribution of pathogenic germline mutations is governed by lineage and penetrance.

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Fig. 1: Dynamic model of carcinogenesis.

References

  1. Broca P. Traité de Tumeurs (P. Asselin, 1866).

  2. Sondka, Z. et al. Nat. Rev. Cancer 18, 696–705 (2018).

    Article  CAS  Google Scholar 

  3. Alexandrov, L. B. et al. Nature 500, 415–421 (2013).

    Article  CAS  Google Scholar 

  4. Knudson, A. G. Proc. Natl Acad. Sci. USA 68, 820–823 (1971).

    Article  Google Scholar 

  5. Rahman, N. Nature 505, 302–308 (2014).

    Article  CAS  Google Scholar 

  6. Park, S. L. et al. Cancer Epidemiol. Biomarkers Prev. 27, 405–417 (2018).

    Article  CAS  Google Scholar 

  7. Srinivasan, P. et al. Nat. Genet. https://doi.org/10.1038/s41588-021-00949-1 (2021).

  8. Huang, K.-l et al. Cell 173, 355–370 (2018).

    Article  CAS  Google Scholar 

  9. Tavtigian, S. et al. Hum. Mutat. 29, 1261–1264 (2008).

    Article  CAS  Google Scholar 

  10. De Andrade, K. et al. Hum. Mutat. 40, 97–105 (2019).

    Article  Google Scholar 

  11. Moore, L. et al. Nature 597, 381–386 (2021).

    Article  CAS  Google Scholar 

  12. Wilkinson, M. D. et al. Sci. Data 6, 174 (2016).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Stephen J. Chanock

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  1. Stephen J. Chanock
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Correspondence to Stephen J. Chanock.

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The author declares no competing interests.

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Chanock, S.J. How the germline informs the somatic landscape. Nat Genet 53, 1523–1525 (2021). https://doi.org/10.1038/s41588-021-00960-6

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