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MUTATIONAL SIGNATURES

Esophageal cancer mutational signatures around the world

Nature Genetics volume 53, pages 1522–1523 (2021)Cite this article

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Mutational signatures can shed light onto mechanisms of carcinogenesis and reveal the mutagenic impact of novel and established environmental risk factors. A new study examines the mutational spectra of esophageal squamous cell cancer together with exposure information in regions of high and low incidence of the disease, and demonstrates both the limitations and potential of mutational signature analyses.

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Fig. 1: Integration of exposures with mutational signatures.

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Authors and Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA, USA

    Marios Giannakis

  2. Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Marios Giannakis

  3. Public Health Sciences Division, Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, WA, USA

    Ulrike Peters

Authors
  1. Marios Giannakis
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  2. Ulrike Peters
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Correspondence to Marios Giannakis or Ulrike Peters.

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Competing interests

M.G. receives research funding from Bristol-Myers Squibb, Merck, Servier and Janssen.

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Giannakis, M., Peters, U. Esophageal cancer mutational signatures around the world. Nat Genet 53, 1522–1523 (2021). https://doi.org/10.1038/s41588-021-00958-0

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