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Misuse of the term ‘trans-ethnic’ in genomics research


A concerning trend in genetics is the common use of the term ‘trans-ethnic’ to describe analyses that combine or compare several ancestrally diverse populations. In this commentary, we discuss how this term is inaccurate and alienating. We propose that geneticists avoid using the term trans-ethnic entirely and that researchers across disciplines reach a new consensus about the best terms to use to describe the populations we study.

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Fig. 1: Increased usage of the term trans-ethnic in PubMed NCBI publications since 2009.


  1. 1.

    Li, W. H. & Sadler, L. A. Genetics 129, 513–523 (1991).

    CAS  Article  Google Scholar 

  2. 2.

    Auton, A. et al. Nature 526, 68–74 (2015).

    Article  Google Scholar 

  3. 3.

    Rosenberg, N. A. et al. PLoS Genet. 1, e70 (2005).

    Article  Google Scholar 

  4. 4.

    Novembre, J. et al. Nature 456, 98–101 (2008).

    CAS  Article  Google Scholar 

  5. 5.

    Barton, N., Hermisson, J. & Nordborg, M. eLife 8, e45380 (2019).

    Article  Google Scholar 

  6. 6.

    Martin, A. R. et al. Nat. Genet. 51, 584–591 (2019).

    CAS  Article  Google Scholar 

  7. 7.

    Popejoy, A. B. et al. Am. J. Hum. Genet. 107, 72–82 (2020).

    CAS  Article  Google Scholar 

  8. 8.

    Birney, E., Inouye, M., Raff, J., Rutherford, A. & Scally, A. Preprint at (2021).

  9. 9.

    Flanagin, A., Frey, T., Christiansen, S. L. & Bauchner, H. J. Am. Med. Assoc. 325, 1049–1052 (2021).

    Article  Google Scholar 

  10. 10.

    Brown, B. C., Ye, C. J., Price, A. L. & Zaitlen, N. Am. J. Hum. Genet. 99, 76–88 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Mägi, R. et al. Hum. Mol. Genet. 26, 3639–3650 (2017).

    Article  Google Scholar 

  12. 12.

    Shi, H. et al. Am. J. Hum. Genet. 106, 805–817 (2020).

    CAS  Article  Google Scholar 

  13. 13.

    Chen, M.-H. et al. Cell 182, 1198–1213.e14 (2020).

    CAS  Article  Google Scholar 

  14. 14.

    Todd, J. A. et al. Nature 338, 587–589 (1989).

    CAS  Article  Google Scholar 

  15. 15.

    McKenzie, C. A. et al. Hum. Mol. Genet. 10, 1077–1084 (2001).

    CAS  Article  Google Scholar 

  16. 16.

    Tekola-Ayele, F. et al. PLoS Genet. 16, e1008747 (2020).

    CAS  Article  Google Scholar 

  17. 17.

    Gouveia, M. H. et al. Sci. Rep. 11, 4075 (2021).

    CAS  Article  Google Scholar 

  18. 18.

    Iyengar, S. K. et al. PLoS Genet. 11, e1005352 (2015).

    Article  Google Scholar 

  19. 19.

    Liu, C.-T. et al. Am. J. Hum. Genet. 99, 56–75 (2016).

    CAS  Article  Google Scholar 

  20. 20.

    van Rooij, F. J. A. et al. Am. J. Hum. Genet. 100, 51–63 (2017).

    Article  Google Scholar 

  21. 21.

    Kichaev, G. & Pasaniuc, B. Am. J. Hum. Genet. 97, 260–271 (2015).

    CAS  Article  Google Scholar 

  22. 22.

    Asimit, J. L., Hatzikotoulas, K., McCarthy, M., Morris, A. P. & Zeggini, E. Eur. J. Hum. Genet. 24, 1330–1336 (2016).

    Article  Google Scholar 

  23. 23.

    Naito, T. et al. Nat. Commun. 12, 1639 (2021).

    CAS  Article  Google Scholar 

  24. 24.

    Morris, A. P. Genet. Epidemiol. 35, 809–822 (2011).

    Article  Google Scholar 

  25. 25.

    Shi, H. et al. Nat. Commun. 12, 1098 (2021).

    CAS  Article  Google Scholar 

  26. 26.

    Guo, J. et al. Sci. Rep. 11, 5240 (2021).

    CAS  Article  Google Scholar 

  27. 27.

    Coram, M. A., Fang, H., Candille, S. I., Assimes, T. L. & Tang, H. Am. J. Hum. Genet. 101, 218–226 (2017).

    CAS  Article  Google Scholar 

  28. 28.

    Cavazos, T. B. & Witte, J. S. Human Genet. Genom. Adv. 2, 100017 (2021).

    Article  Google Scholar 

  29. 29.

    Giri, A. et al. Nat. Genet. 51, 51–62 (2019).

    CAS  Article  Google Scholar 

  30. 30.

    Mariner, K.A. Contingent Kinship: The Flows and Futures of Adoption in the United States (Univ. California Press, 2019).

  31. 31.

    Brubaker, R. Trans: Gender and Race in an Age of Unsettled Identities (Princeton Univ.Press, 2016).

  32. 32.

    Bureau, U.C. About Race. The United States Census Bureau (accessed 12 May 2021).

  33. 33.

    Bryc, K., Durand, E. Y., Macpherson, J. M., Reich, D. & Mountain, J. L. Am. J. Hum. Genet. 96, 37–53 (2015).

    CAS  Article  Google Scholar 

  34. 34.

    Yudell, M., Roberts, D., DeSalle, R. & Tishkoff, S. Science 351, 564–565 (2016).

    CAS  Article  Google Scholar 

  35. 35.

    Green, E. D. et al. Nature 586, 683–692 (2020).

    CAS  Article  Google Scholar 

  36. 36.

    Bonham, V. L., Callier, S. L. & Royal, C. D. N. Engl. J. Med. 374, 2003–2005 (2016).

    Article  Google Scholar 

  37. 37.

    Bonham, V. L., Green, E. D. & Pérez-Stable, E. J. J. Am. Med. Assoc. 320, 1533–1534 (2018).

    Article  Google Scholar 

  38. 38.

    Kevles, D.J. In the Name of Eugenics: Genetics and the Uses of Human Heredity (Harvard Univ. Press, 1995).

  39. 39.

    Roberts, D. Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-First Century (New Press/ORIM, 2011).

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We thank A. Bloemendal, S. Callier, A. Jabloner, E. Hammonds, B. Ogbunu, A. Price, D. Reich and P. Turley for critical reading and comments on this manuscript. L.C. is supported by an Alfred P. Sloan Research Fellowship and a David & Lucile Packard Fellowship for Science and Engineering. H.F. was supported by NIH DP5 OD024582.

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All authors contributed equally.

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Correspondence to Mireille Kamariza, Lorin Crawford, David Jones or Hilary Finucane.

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The authors declare no competing interests.

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Kamariza, M., Crawford, L., Jones, D. et al. Misuse of the term ‘trans-ethnic’ in genomics research. Nat Genet 53, 1520–1521 (2021).

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