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CANCER EPIGENETICS

Epigenomic contributions to tumor cell heterogeneity and plasticity

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A Publisher Correction to this article was published on 20 October 2021

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Heterogeneity in brain tumors has been viewed through many lenses—from microscopes and experimental models to ‘omic’ analysis at the tissue and single-cell levels. Two studies now characterize patterns of DNA methylation and gene expression in single cells to reveal epigenomic underpinnings of cellular heterogeneity and plasticity in exquisite detail, including mechanistic insight into cellular transitions between stem-like and differentiated-like states.

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Fig. 1: Epigenetic mechanisms contributing to tumor cell heterogeneity and plasticity.

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References

  1. Marusyk, A., Janiszewska, M. & Polyak, K. Cancer Cell. 37, 471–484 (2020).

    Article  CAS  Google Scholar 

  2. Nicholson, J. G. & Fine, H. A. Cancer Discov. 11, 575–590 (2021).

    Article  CAS  Google Scholar 

  3. Venteicher, A. S. et al. Science 355, eaai8478 (2017).

    Article  Google Scholar 

  4. Neftel, C., Laffy, J., Filbin, M. G., Hara, T., Shore, M. E. & Rahme, G. J. et al. Cell 178, 835–849.e21 (2019).

    Article  CAS  Google Scholar 

  5. Chaligne, R. et al. Nat. Genet. https://doi.org/10.1038/s41588-021-00927-7 (2021).

  6. Johnson, K. C. et al. Nat. Genet. https://doi.org/10.1038/s41588-021-00926-8 (2021).

  7. Noushmehr, H. et al. Cancer Cell 17, 510–522 (2010).

    Article  CAS  Google Scholar 

  8. Capper, D. et al. Nature 555, 469–474 (2018).

    Article  CAS  Google Scholar 

  9. Ceccarelli, M. et al. Cell 164, 550–563 (2016).

    Article  CAS  Google Scholar 

  10. Wang, Q. et al. Cancer Cell 32, 42–56 (2017).

    Article  Google Scholar 

  11. Flavahan, W. et al. Nature 529, 110–114 (2016).

    Article  CAS  Google Scholar 

  12. Schlesinger, Y. et al. Nat. Genet. 39, 232–236 (2007).

    Article  CAS  Google Scholar 

  13. Widschwendter, M. et al. Nat. Genet. 39, 157–158 (2007).

    Article  CAS  Google Scholar 

  14. Ohm, J. E. et al. Nat. Genet. 39, 237–242 (2007).

    Article  CAS  Google Scholar 

  15. Thienpont, B. et al. Nature 537, 63–68 (2016).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Joseph F. Costello.

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Mathur, R., Costello, J.F. Epigenomic contributions to tumor cell heterogeneity and plasticity. Nat Genet 53, 1403–1404 (2021). https://doi.org/10.1038/s41588-021-00932-w

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