Heterogeneity in brain tumors has been viewed through many lenses—from microscopes and experimental models to ‘omic’ analysis at the tissue and single-cell levels. Two studies now characterize patterns of DNA methylation and gene expression in single cells to reveal epigenomic underpinnings of cellular heterogeneity and plasticity in exquisite detail, including mechanistic insight into cellular transitions between stem-like and differentiated-like states.
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Change history
20 October 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00966-0
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Mathur, R., Costello, J.F. Epigenomic contributions to tumor cell heterogeneity and plasticity. Nat Genet 53, 1403–1404 (2021). https://doi.org/10.1038/s41588-021-00932-w
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DOI: https://doi.org/10.1038/s41588-021-00932-w
