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Extreme conservation encodes the structural dynamics and function of 5′ UTRs

RNA is dynamic and can fold into multiple alternative conformations. A new study shows that cells control mRNA translation by regulating the stoichiometry of alternative RNA structures formed from extremely conserved sequences of 5′ untranslated regions and that this control may contribute to embryonic development.

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Fig. 1: h5UTRs may act as key regulators of translation during vertebrate development.


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Correspondence to Jean-Denis Beaudoin.

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Gupta, A., Beaudoin, JD. Extreme conservation encodes the structural dynamics and function of 5′ UTRs. Nat Genet 53, 591–592 (2021).

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