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Linking human sympathoadrenal development and neuroblastoma

Cells resembling human fetal adrenal neuroblasts have been identified as major neuroblastoma cancer cells through single-cell mRNA comparison. Tumor risk stratification correlates with the differentiation of neuroblast-like neuroblastoma cells.

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Fig. 1: Schematic illustration of the changing composition of the human adrenal medulla during fetal development and the correlation with the stage-dependent composition of neuroblastoma.


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Correspondence to Hermann Rohrer.

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Rohrer, H. Linking human sympathoadrenal development and neuroblastoma. Nat Genet 53, 593–594 (2021).

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