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A resource of targeted mutant mouse lines for 5,061 genes

The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

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Fig. 1: Generation and effects of targeted alleles for 5,061 unique mouse genes.

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Acknowledgements

We thank all technical personnel at the different centers involved in this project for their contributions. We thank G. Clarke for support with illustrations. M.-C.B., G.P., M.W.-D., Y.H. and T.S. were supported by the Université de Strasbourg, the CNRS, the INSERM and the ‘Investissements d'avenir’ programs (ANR-10-IDEX-0002-02, ANR-10-LABX-0030-INRT and ANR-10-INBS-07 PHENOMIN); A.Y. and M.T. were supported by a RIKEN BioResource Research Center (BRC), Management Expenses Grant from the Ministry of Education, Culture, Sports, Science and Technology (MEXT); D.A., J.B., A. Bradley, W.B., B.D., S.N., R.R.S., B.R., E.R., W.S., K.S. and H.W.-J. were supported by the Wellcome Trust; S.B., S.C., G.C., M.F., S.W. and L.T. were supported by the Medical Research Council (A410); M.G., C.M. and L.N. were supported by Genome Canada and Ontario Genomics (OGI-051); H.L., Y.J.L., G.T.O. and J.K.S. were supported by the National Research Foundation (2014M3A9D5A01074636, 2014M3A9D5A01075128 and 2013M3A9D5072550), Republic of Korea (KMPC); M.B., A. Bradley, S.B., A. Bürger, W.B., F.C., M.F., A.G., M.H.d.A., R.K., S.N., G.P., R.R.S., B.R., E.R., J.S., W.S., C.S., T.S., G.T.-V., S.W., W.W. and L.T. were supported by the European Commission (EUCOMM (LSHM-CT-2005-018931), EUCOMMTOOLS (FP7-HEALTH-F4-2010-261492), EUMODIC, Infrafrontier 01KX1012 (M.H.d.A.) and EU Horizon 2020: IPAD-MD funding 653961 (M.H.d.A.)); R.S. and P.K. were supported by RVO 68378050 from the Academy of Sciences of the Czech Republic and by LM2015040 and LM2018126 (Czech Centre for Phenogenomics), CZ.1.05/2.1.00/19.0395 and CZ.1.05/1.1.00/02.0109 funded by the Ministry of Education, Youth and Sports and the European Regional Development Fund. Work was supported by the National Key R&D Program of China 2018YFA0801100 to Y.X. Research reported in this publication was supported by the NIH Common Fund, the Office of The Director and the National Human Genomic Research Institute of the National Institutes of Health (U42OD011174 supported A.L.B., J.B., A. Bradley, W.B., B.D., M.D., M.F., J. H., M.J., I.L., F.M., S.N., R.R.S., B.R., E.R., W.S., J.S., S.W. and L.T.; U42OD011175 supported M.G., C.M., L.N., B.W., J.W. and K.C.L.; U42OD011185 supported L.R.D., L.G., M.V.W. and S.A.M.; U54HG006370-02 supported A.G.-S., R.E.K., A.-M.M., T.M., V.M.F. and L.S.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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M.-C.B., A.Y., S.A., J.B., A. Bürger, W.B., F.C., S.C., G.F.C., F.J.D., B.D., M.D.F., A.G., M.G., A.G.-S., L.O.G., P.K., R.E.K., R.K., H.L., Y.J.L., I.L., A.-M.M., T.F.M., V.M.F., S.N., L.M.J.N., G.T.O., G.P., R.R.-S., B.R., E.J.R., L.A.S., J.S., J.R.S., C.S., M.T., H.W.-J., M.W.-D., M.V.W., B.J.W., J.A.W., L.T., S.A.M. and the IMPC generated data, developed data tools and databases, and/or performed data and statistical analyses; A.Y., D.J.A., A.L.B., A. Bradley, S.D.M.B., H.-J.G.C., M.E.D., L.R.D., X.G., J.D.H., Y.H., M.H.d.A., S.-T.J., M.J.J., Z.L., K.C.K.L., C.M., A.-M.M., T.F.M., L.M.J.N., R.S., J.K.S., W.C.S., T.S., K.P.S., G.P.T.-V., C.-K.L.W., S.W., W.W., Y.X., L.T. and S.A.M. directed research at their respective institutions; M.-C.B., L.T. and S.A.M. wrote the paper.

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Correspondence to Lydia Teboul or Stephen A. Murray.

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Supplementary Information

Supplementary Methods, Figs. 1–6, Tables 2 and 3, and Note

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Supplementary Table 1

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Birling, MC., Yoshiki, A., Adams, D.J. et al. A resource of targeted mutant mouse lines for 5,061 genes. Nat Genet 53, 416–419 (2021). https://doi.org/10.1038/s41588-021-00825-y

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