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A resource of targeted mutant mouse lines for 5,061 genes

Nature Genetics volume 53, pages 416–419 (2021)Cite this article

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The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

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Fig. 1: Generation and effects of targeted alleles for 5,061 unique mouse genes.

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Acknowledgements

We thank all technical personnel at the different centers involved in this project for their contributions. We thank G. Clarke for support with illustrations. M.-C.B., G.P., M.W.-D., Y.H. and T.S. were supported by the Université de Strasbourg, the CNRS, the INSERM and the ‘Investissements d'avenir’ programs (ANR-10-IDEX-0002-02, ANR-10-LABX-0030-INRT and ANR-10-INBS-07 PHENOMIN); A.Y. and M.T. were supported by a RIKEN BioResource Research Center (BRC), Management Expenses Grant from the Ministry of Education, Culture, Sports, Science and Technology (MEXT); D.A., J.B., A. Bradley, W.B., B.D., S.N., R.R.S., B.R., E.R., W.S., K.S. and H.W.-J. were supported by the Wellcome Trust; S.B., S.C., G.C., M.F., S.W. and L.T. were supported by the Medical Research Council (A410); M.G., C.M. and L.N. were supported by Genome Canada and Ontario Genomics (OGI-051); H.L., Y.J.L., G.T.O. and J.K.S. were supported by the National Research Foundation (2014M3A9D5A01074636, 2014M3A9D5A01075128 and 2013M3A9D5072550), Republic of Korea (KMPC); M.B., A. Bradley, S.B., A. Bürger, W.B., F.C., M.F., A.G., M.H.d.A., R.K., S.N., G.P., R.R.S., B.R., E.R., J.S., W.S., C.S., T.S., G.T.-V., S.W., W.W. and L.T. were supported by the European Commission (EUCOMM (LSHM-CT-2005-018931), EUCOMMTOOLS (FP7-HEALTH-F4-2010-261492), EUMODIC, Infrafrontier 01KX1012 (M.H.d.A.) and EU Horizon 2020: IPAD-MD funding 653961 (M.H.d.A.)); R.S. and P.K. were supported by RVO 68378050 from the Academy of Sciences of the Czech Republic and by LM2015040 and LM2018126 (Czech Centre for Phenogenomics), CZ.1.05/2.1.00/19.0395 and CZ.1.05/1.1.00/02.0109 funded by the Ministry of Education, Youth and Sports and the European Regional Development Fund. Work was supported by the National Key R&D Program of China 2018YFA0801100 to Y.X. Research reported in this publication was supported by the NIH Common Fund, the Office of The Director and the National Human Genomic Research Institute of the National Institutes of Health (U42OD011174 supported A.L.B., J.B., A. Bradley, W.B., B.D., M.D., M.F., J. H., M.J., I.L., F.M., S.N., R.R.S., B.R., E.R., W.S., J.S., S.W. and L.T.; U42OD011175 supported M.G., C.M., L.N., B.W., J.W. and K.C.L.; U42OD011185 supported L.R.D., L.G., M.V.W. and S.A.M.; U54HG006370-02 supported A.G.-S., R.E.K., A.-M.M., T.M., V.M.F. and L.S.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Author information

Author notes

  1. Arthur L. Beaudet

    Present address: Luna Genetics, Houston, TX, USA

  2. Allan Bradley

    Present address: Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK

  3. Wendy Bushell

    Present address: IONTAS, Cambridge, UK

  4. Francesco J. DeMayo

    Present address: National Institute for Environmental Health Science Research, Durham, NC, USA

  5. Ralf Kühn

    Present address: Max Delbrueck Center for Molecular Medicine, Berlin, Germany

  6. Ralf Kühn

    Present address: Berlin Institute of Health, Berlin, Germany

  7. Terrence F. Meehan

    Present address: Kymab Group, Cambridge, UK

  8. Stuart Newman

    Present address: PetMedix, Cambridge, UK

  9. Barry Rosen

    Present address: AstraZeneca, Discovery Sciences, Cambridge, UK

  10. Edward J. Ryder

    Present address: LGC, Sport and Specialised Analytical Services, Fordham, UK

  11. Joel Schick

    Present address: Genetics and Cellular Engineering Group, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Neuherberg, Germany

  12. William C. Skarnes

    Present address: The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA

  13. Karen P. Steel

    Present address: Wolfson Centre for Age-Related Diseases, King’s College London, London, UK

Authors and Affiliations

  1. Université de Strasbourg, CNRS, INSERM, PHENOMIN-ICS, IGBMC, Illkirch, France

    Marie-Christine Birling, Yann Hérault, Guillaume Pavlovic, Tania Sorg, Marie Wattenhofer-Donzé, Mohammed Selloum, Sylvie Jacquot, Abdel Ayadi, Dalila Ali-Hadji, Philippe Charles, Elise Le Marchand, Amal El Amri, Christelle Kujath, Jean-Victor Fougerolle, Peggy Mellul, Sandrine Legeay, Laurent Vasseur, Anne-Isabelle Moro, Romain Lorentz, Laurence Schaeffer, Dominique Dreyer, Valérie Erbs, Benjamin Eisenmann, Giovanni Rossi, Laurence Luppi, Annelyse Mertz & Amélie Jeanblanc

  2. RIKEN BioResource Research Center, Tsukuba, Japan

    Atsushi Yoshiki, Shinya Ayabe, Masaru Tamura, Yuichi Obata, Mizuho Iwama, Hatsumi Nakata, Tomomi Hashimoto, Masayo Kadota, Hiroshi Masuya, Nobuhiko Tanaka, Ikuo Miura, Ikuko Yamada & Tamio Furuse

  3. Wellcome Sanger Institute, Hinxton, UK

    David J. Adams, Joanna Bottomley, Allan Bradley, Wendy Bushell, Brendan Doe, Stuart Newman, Ramiro Ramirez-Solis, Barry Rosen, Edward J. Ryder, William C. Skarnes, Karen P. Steel, Hannah Wardle-Jones, Evelyn Grau, Caroline Sinclair, Ellen Brown, Helen Kundi, Alla Madich, Mike Woods, Laila Pearson, Danielle Mayhew, Nicola Griggs, Richard Houghton, James Bussell, Catherine Ingle, Sara Valentini, Diane Gleeson, Debarati Sethi, Tanya Bayzetinova, Jonathan Burvill, Bishoy Habib, Lauren Weavers, Ryea Maswood, Evelina Miklejewska, Ross Cook, Radka Platte, Stacey Price, Sapna Vyas, Adam Collinson, Matt Hardy, Priya Dalvi, Vivek Iyer, Tony West, Mark Thomas, Alejandro Mujica, Elodie Sins & Daniel Barrett

  4. Baylor College of Medicine, Houston, TX, USA

    Arthur L. Beaudet, Francesco J. DeMayo, Mary E. Dickinson, Jason D. Heaney, Monica J. Justice, Isabel Lorenzo, John R. Seavitt, Juan J. Gallegos, Jennie R. Green, Ritu Bohat & Katie Zimmel

  5. MRC Harwell Institute, Mammalian Genetics Unit, Didcot, UK

    Steve D. M. Brown, Ruairidh E. King, Ann-Marie Mallon, Luis A. Santos, Mohamed M. Quwailid, Rumana Zaman & Luis Santos

  6. Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    Antje Bürger, Ralf Kühn, Joel Schick, Claudia Seisenberger, Wolfgang Wurst, Roland Friedel, Cornelia Kaloff, Andreas Hörlein, Sandy Teichmann, Adriane Tasdemir, Heidi Krause, Dorota German, Anne Könitzer, Sarah Weber & Joachim Beig

  7. Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo, Italy

    Francesco Chiani, Alessia Gambadoro & Glauco P. Tocchini-Valentini

  8. National Laboratory Animal Center, National Applied Research Laboratories (NARLabs), Taipei, Taiwan

    Hsian-Jean Genie Chin, Si-Tse Jiang & Chi-Kuang Leo Wang

  9. MRC Harwell Institute, Mary Lyon Centre, Didcot, UK

    Skevoulla Christou, Gemma F. Codner, Martin D. Fray, Sara Wells, Wendy Gardiner, Toni Bell, Janet Kenyon, Michelle E. Stewart, Denise Lynch, Jorik Loeffler, Adam Caulder, Rosie Hillier & Lydia Teboul

  10. The Jackson Laboratory, Bar Harbor, ME, USA

    Leah Rae Donahue, Leslie O. Goodwin, Michael V. Wiles, Matthew McKay, Richard Bedigian, Stephanie Dion, Peter Kutny, Jennifer Kelmenson, Emily Perry, Dong Nguyen-Bresinsky, Audrie Seluke, Timothy Leach, Sara Perkins, Amanda Slater, Michaela Petit, Rachel Urban, Susan Kales, Michael DaCosta, Michael McFarland, Rick Palazola, Kevin A. Peterson, Karen Svenson, Robert E. Braun, Robert Taft & Stephen A. Murray

  11. SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China

    Xiang Gao

  12. Centre for Phenogenomics, Toronto, Ontario, Canada

    Marina Gertsenstein, Monica J. Justice, Colin McKerlie, Lauryl M. J. Nutter, Monica Pereira, Suzanne MacMaster, Sandra Tondat, Linda Wei, Tracy Carroll, Jorge Cabezas, Qing Fan-Lan, Elsa Jacob, Amie Creighton, Patricia Castellanos-Penton, Ozge Danisment, Shannon Clarke, Joanna Joeng, Deborah Kelly, Christine To & Rebekah van Bruggen

  13. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK

    Alba Gomez-Segura, Terrence F. Meehan & Violeta Munoz Fuentes

  14. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    Martin Hrabe de Angelis, Valerie Gailus-Durner, Helmut Fuchs, Susan Marschall, Stefanie Dunst, Markus Romberger & Bernhard Rey

  15. Experimental Genetics, Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany

    Martin Hrabe de Angelis

  16. German Center for Diabetes Research, Neuherberg, Germany

    Martin Hrabe de Angelis

  17. Hospital for Sick Children, Toronto, Ontario, Canada

    Monica J. Justice, Colin McKerlie & Lauryl M. J. Nutter

  18. Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic

    Petr Kasparek & Radislav Sedlacek

  19. Korea Mouse Phenotyping Center (KMPC) and Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi, Republic of Korea

    Ho Lee

  20. Korea Mouse Phenotyping Center (KMPC) and Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea

    Young Jae Lee

  21. CAM-SU Genomic Resource Center, Soochow University, Suzhou, China

    Zhiwei Liu & Ying Xu

  22. Mouse Biology Program, University of California, Davis, Davis, CA, USA

    K. C. Kent Lloyd, Brandon J. Willis, Joshua A. Wood, Mark Rhue, Jose Garay, Dave Clary, Renee Araiza, Kristin Grimsrud, Lynette Bower, Nicole L. Anchell, Kayla M. Jager, Diana L. Young & Phuong T. Dao

  23. Immune and Vascular Cell Network Research Center, National Creative Initiatives and Department of Life Sciences, Ewha Womans Univesity, Seoul, Republic of Korea

    Goo Taeg Oh

  24. Korea Mouse Phenotyping Center (KMPC) and BK21 Program for Veterinary Science, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea

    Je Kyung Seong

  25. Developmental Genetics, Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany

    Wolfgang Wurst

  26. German Center for Neurodegenerative Diseases, Munich, Germany

    Wolfgang Wurst

  27. INFRAFRONTIER, Munich, Germany

    Sabine Fessele & Philipp Gormanns

  28. Phenomics Australia, John Curtin School of Medical Research, Australian National University, Acton, Canberra, Australia

    Michael Dobbie

  29. PCDDP, North-West University, Potchefstroom, South Africa

    Anne Grobler, Glaudina Loots, Rose Hayeshi, Liezl-Marie Scholtz, Cor Bester, Wihan Pheiffer & Kobus Venter

  30. Universitat Autònoma de Barcelona, Barcelona, Spain

    Fatima Bosch

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Consortia

International Mouse Phenotyping Consortium (IMPC)

  • Juan J. Gallegos
  • , Jennie R. Green
  • , Ritu Bohat
  • , Katie Zimmel
  • , Monica Pereira
  • , Suzanne MacMaster
  • , Sandra Tondat
  • , Linda Wei
  • , Tracy Carroll
  • , Jorge Cabezas
  • , Qing Fan-Lan
  • , Elsa Jacob
  • , Amie Creighton
  • , Patricia Castellanos-Penton
  • , Ozge Danisment
  • , Shannon Clarke
  • , Joanna Joeng
  • , Deborah Kelly
  • , Christine To
  • , Rebekah van Bruggen
  • , Valerie Gailus-Durner
  • , Helmut Fuchs
  • , Susan Marschall
  • , Stefanie Dunst
  • , Markus Romberger
  • , Bernhard Rey
  • , Sabine Fessele
  • , Philipp Gormanns
  • , Roland Friedel
  • , Cornelia Kaloff
  • , Andreas Hörlein
  • , Sandy Teichmann
  • , Adriane Tasdemir
  • , Heidi Krause
  • , Dorota German
  • , Anne Könitzer
  • , Sarah Weber
  • , Joachim Beig
  • , Matthew McKay
  • , Richard Bedigian
  • , Stephanie Dion
  • , Peter Kutny
  • , Jennifer Kelmenson
  • , Emily Perry
  • , Dong Nguyen-Bresinsky
  • , Audrie Seluke
  • , Timothy Leach
  • , Sara Perkins
  • , Amanda Slater
  • , Michaela Petit
  • , Rachel Urban
  • , Susan Kales
  • , Michael DaCosta
  • , Michael McFarland
  • , Rick Palazola
  • , Kevin A. Peterson
  • , Karen Svenson
  • , Robert E. Braun
  • , Robert Taft
  • , Mark Rhue
  • , Jose Garay
  • , Dave Clary
  • , Renee Araiza
  • , Kristin Grimsrud
  • , Lynette Bower
  • , Nicole L. Anchell
  • , Kayla M. Jager
  • , Diana L. Young
  • , Phuong T. Dao
  • , Wendy Gardiner
  • , Toni Bell
  • , Janet Kenyon
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  • , Diane Gleeson
  • , Debarati Sethi
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  • , Jonathan Burvill
  • , Bishoy Habib
  • , Lauren Weavers
  • , Ryea Maswood
  • , Evelina Miklejewska
  • , Ross Cook
  • , Radka Platte
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  • , Adam Collinson
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  • , Cor Bester
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  • , Kobus Venter
  •  & Fatima Bosch

Contributions

M.-C.B., A.Y., S.A., J.B., A. Bürger, W.B., F.C., S.C., G.F.C., F.J.D., B.D., M.D.F., A.G., M.G., A.G.-S., L.O.G., P.K., R.E.K., R.K., H.L., Y.J.L., I.L., A.-M.M., T.F.M., V.M.F., S.N., L.M.J.N., G.T.O., G.P., R.R.-S., B.R., E.J.R., L.A.S., J.S., J.R.S., C.S., M.T., H.W.-J., M.W.-D., M.V.W., B.J.W., J.A.W., L.T., S.A.M. and the IMPC generated data, developed data tools and databases, and/or performed data and statistical analyses; A.Y., D.J.A., A.L.B., A. Bradley, S.D.M.B., H.-J.G.C., M.E.D., L.R.D., X.G., J.D.H., Y.H., M.H.d.A., S.-T.J., M.J.J., Z.L., K.C.K.L., C.M., A.-M.M., T.F.M., L.M.J.N., R.S., J.K.S., W.C.S., T.S., K.P.S., G.P.T.-V., C.-K.L.W., S.W., W.W., Y.X., L.T. and S.A.M. directed research at their respective institutions; M.-C.B., L.T. and S.A.M. wrote the paper.

Corresponding authors

Correspondence to Lydia Teboul or Stephen A. Murray.

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The authors declare no competing interests.

Supplementary information

Supplementary Information

Supplementary Methods, Figs. 1–6, Tables 2 and 3, and Note

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Supplementary Table 1

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Birling, MC., Yoshiki, A., Adams, D.J. et al. A resource of targeted mutant mouse lines for 5,061 genes. Nat Genet 53, 416–419 (2021). https://doi.org/10.1038/s41588-021-00825-y

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