Case–case genome-wide association studies (GWAS) within a single genotyped cohort have proven useful in identifying genetic variants explaining different health outcomes, yet they are limited by data availability. A new study by Peyrot and Price proposes a clever statistical method to overcome this problem by inferring case–case GWAS results from a pair of standard case–control GWAS summary statistics that need not be from the same cohort.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pasaniuc, B. & Price, A. L. Nat. Rev. Genet. 18, 117–127 (2017).
Lambert, S. A., Abraham, G. & Inouye, M. Hum. Mol. Genet. 28, R133–R142 (2019).
Wray, N. R. et al. Nat. Rev. Genet. 14, 507–515 (2013).
Finucane, H. K. et al. Nat. Genet. 47, 1228–1235 (2015).
Bulik-Sullivan, B. et al. Nat. Genet. 47, 1236–1241 (2015).
Turley, P. et al. Nat. Genet. 50, 229–237 (2018).
Julienne, H. et al. Preprint at bioRxiv https://doi.org/10.1101/2020.06.26.172999 (2020).
Grotzinger, A. D. et al. Nat. Hum. Behav. 3, 513–525 (2019).
Zhu, Z. et al. Nat. Commun. 9, 224 (2018).
O’Connor, L. J. & Price, A. L. Nat. Genet. 50, 1753 (2018).
Porcu, E. et al. Nat. Commun. 10, 3300 (2019).
Hartwig, F. P., Davies, N. M., Hemani, G. & Davey Smith, G. Int. J. Epidemiol. 45, 1717–1726 (2016).
Peyrot, W. J. & Price, A. L. Nat. Genet. https://doi.org/10.1038/s41588-021-00787-1 (2021).
Byrne, E. M. et al. Mol. Psychiatry https://doi.org/10.1038/s41380-020-0705-9 (2020).
Demange, P. A. et al. Nat. Genet. 53, 35–44 (2021).
Acknowledgements
F.P., Z.Z. and B.J.V. are supported by the Danish National Research Foundation (Niels Bohr Professorship to J. McGrath) and also acknowledge the Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH (R248-2017-2003). B.J.V. is also supported by a Lundbeck Foundation Fellowship (R335-2019-2339).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Privé, F., Zhu, Z. & Vilhjalmsson, B.J. Finding hidden treasures in summary statistics from genome-wide association studies. Nat Genet 53, 431–432 (2021). https://doi.org/10.1038/s41588-021-00824-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-021-00824-z
