The nucleosome remodeling and deacetylase (NuRD) complex is a chromatin modifier with a key role in the switch from fetal to adult hemoglobin. In a new study, Vinjamur et al. identify a fetal hemoglobin repressor, ZNF410, which does not directly bind the γ-globin promoter but acts through highly specific regulation of CHD4, a protein subunit of the NuRD complex, thus presenting a potential approach for therapeutic reactivation of fetal hemoglobin.
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Tumburu, L., Thein, S.L. Targeting ZNF410 as a potential β-hemoglobinopathy therapy. Nat Genet 53, 589–590 (2021). https://doi.org/10.1038/s41588-021-00817-y