Extended Data Fig. 1: KRAS putative functional and neutral mutations. | Nature Genetics

Extended Data Fig. 1: KRAS putative functional and neutral mutations.

From: Discovering functional evolutionary dependencies in human cancers

Extended Data Fig. 1

a) KRAS gene essentiality across the cancer cell lines in the AVANA dataset (Y axis - negative scores indicate greater gene essentiality). Cancer cell lines are classified according to KRAS mutations (nG12 = 69, nother_drivers_ = 16, nneutral = 7, nwt = 389). b) 3D spatial conformation of the KRAS protein (PDB ID: 5OCG). Amino acids hit by functional single nucleotide variants are colored.

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