Extended Data Fig. 9: Evolutionary Axes across tumor types. | Nature Genetics

Extended Data Fig. 9: Evolutionary Axes across tumor types.

From: Discovering functional evolutionary dependencies in human cancers

Extended Data Fig. 9

a) Schematic of the procedure to map EDs identified by SELECT in the pan-cancer and single tumor type studies to a given cohort of interest. b–d) Evolutionary axes inferred for (b) brain tumors (low grade glioma and glioblastoma cohorts), (c) gastric tumors (colorectal and stomach cancer cohorts), and (d) squamous cell carcinomas (lung squamous cell, head and neck, esophageal cancer cohorts). Axes comprise mutually exclusive (purple edges) and co-occurrent (green edges) EDs between altered oncogenes (red circles) and tumor suppressors (blue circles).

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