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PROSTATE CANCER

Targeting LSD1 and FOXA1 in prostate cancer

FOXA1 is a key pioneer factor in androgen-receptor activity but has been an elusive drug target. A new study shows that inhibition of the associated cofactor LSD1 modifies the methylation state of FOXA1, thus resulting in chromatin dissociation and tumor inhibition, even in models of treatment-resistant prostate cancer.

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Fig. 1: LSD1-dependent FOXA1 demethylation promotes recruitment of AR to target genes.

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Correspondence to Jason S. Carroll.

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Omarjee, S., Carroll, J.S. Targeting LSD1 and FOXA1 in prostate cancer. Nat Genet 52, 1002–1003 (2020). https://doi.org/10.1038/s41588-020-0702-6

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