Fig. 1: Population variation across the spike–ACE2 complex. | Nature Genetics

Fig. 1: Population variation across the spike–ACE2 complex.

From: Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource

Fig. 1

a, Lollipop plots of circulating missense variants in the SARS-CoV-2 spike protein and population-specific missense variants in human ACE2 illustrate the broad distribution of variants across the proteins. b, When visualized spatially, several variants seen at the ACE2–spike interface are predicted to affect the binding affinity. One of the most prevalent circulating SARS-CoV2 spike variants, p.Asp614Gly, is located far from the ACE2 interface but close to the spike-trimer interface and is predicted to lead to structural perturbations.

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