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EPIGENOMICS

RNA closing the Polycomb circle

Nature Genetics volume 52, pages 866–867 (2020)Cite this article

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Binding of RNA to the gene expression regulator Polycomb repressive complex 2 (PRC2) has been proposed to antagonize PRC2’s chromatin recruitment. A new study now shows that RNA is in fact critical for correct recruitment of PRC2 at its target genes in human pluripotent stem cells and suggests that interplay of PRC2 and RNA can fine-tune PRC2’s regulatory role.

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Fig. 1: Chromatin features influencing PRC2 occupancy.

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Authors and Affiliations

  1. Center for Genomic Regulation, Barcelona, Spain

    Ivano Mocavini & Luciano Di Croce

  2. Barcelona Institute of Science and Technology, Barcelona, Spain

    Ivano Mocavini & Luciano Di Croce

  3. ICREA, Barcelona, Spain

    Luciano Di Croce

  4. Pompeu Fabra University, Barcelona, Spain

    Luciano Di Croce

Authors
  1. Ivano Mocavini
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  2. Luciano Di Croce
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Correspondence to Ivano Mocavini or Luciano Di Croce.

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The authors declare no competing interests.

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Mocavini, I., Di Croce, L. RNA closing the Polycomb circle. Nat Genet 52, 866–867 (2020). https://doi.org/10.1038/s41588-020-0683-5

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