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3D GENOMICS

TADs without borders

Genomes are highly organized in space and time. Compartments, topologically associating domains (TADs) and loops are three dimensional (3D) genome features that have been extensively studied. Among these three levels of organization, TADs have sparked the most debate. New microscopy data shed light on how TADs and their leaky borders contribute to gene regulation.

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Fig. 1: Using light microscopy to characterize border permeability in 3D genome structures.

References

  1. Corces, V. Twitter https://twitter.com/CorcesVictor/status/1120698678535180289 (23 April 2019).

  2. Luppino, J. M. et al. Nat. Genet. https://doi.org/s41588-020-0647-9 (2020).

  3. Dixon, J. R. et al. Nature 485, 376–380 (2012).

    Article  CAS  Google Scholar 

  4. Nora, E. P. et al. Nature 485, 381–385 (2012).

    Article  CAS  Google Scholar 

  5. Rao, S. S. et al. Cell 159, 1665–1680 (2014).

    Article  CAS  Google Scholar 

  6. Chang, L. H., Ghosh, S. & Noordermeer, D. J. Mol. Biol. 432, 643–652 (2020).

    Article  CAS  Google Scholar 

  7. Alipour, E. & Marko, J. F. Nucleic Acids Res. 40, 11202–11212 (2012).

    Article  CAS  Google Scholar 

  8. Fudenberg, G. et al. Cell Rep. 15, 2038–2049 (2016).

    Article  CAS  Google Scholar 

  9. Sanborn, A. L. et al. Proc. Natl Acad. Sci. USA 112, E6456–E6465 (2015).

    Article  CAS  Google Scholar 

  10. Cattoni, D. I. et al. Nat. Commun. 8, 1753 (2017).

    Article  Google Scholar 

  11. Bintu, B. et al. Science 362, eaau1783 (2018).

    Article  Google Scholar 

  12. Rao, S. S. P. et al. Cell 171, 305–320.e24 (2017).

    Article  CAS  Google Scholar 

  13. Nora, E. P. et al. Cell 169, 930–944.e22 (2017).

    Article  CAS  Google Scholar 

  14. Despang, A. et al. Nat. Genet. 51, 1263–1271 (2019).

    Article  CAS  Google Scholar 

  15. Beliveau, B. J. et al. Nat. Commun. 6, 7147 (2015).

    Article  CAS  Google Scholar 

  16. Wang, S. et al. Science 353, 598–602 (2016).

    Article  CAS  Google Scholar 

  17. Nir, G. et al. PLoS Genet. 14, e1007872 (2018).

    Article  Google Scholar 

  18. Kojic, A. et al. Nat. Struct. Mol. Biol. 25, 496–504 (2018).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Marc A. Marti-Renom.

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Farabella, I., Marti-Renom, M.A. TADs without borders. Nat Genet 52, 752–753 (2020). https://doi.org/10.1038/s41588-020-0670-x

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