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TADs without borders

Genomes are highly organized in space and time. Compartments, topologically associating domains (TADs) and loops are three dimensional (3D) genome features that have been extensively studied. Among these three levels of organization, TADs have sparked the most debate. New microscopy data shed light on how TADs and their leaky borders contribute to gene regulation.

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Fig. 1: Using light microscopy to characterize border permeability in 3D genome structures.


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Correspondence to Marc A. Marti-Renom.

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Farabella, I., Marti-Renom, M.A. TADs without borders. Nat Genet 52, 752–753 (2020).

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