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Navigating the path to distant metastasis

How ‘difficult’ is it for somatic evolution to produce a cell that is capable of leaving the primary tumor and growing in a distant organ? In this issue, Reiter et al. assess genetic diversity across metastatic lesions and identify a tight selective bottleneck preceding distant metastasis.

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Fig. 1: Selective bottlenecks in metastasis.


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Correspondence to Trevor A. Graham or Darryl Shibata.

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Graham, T.A., Shibata, D. Navigating the path to distant metastasis. Nat Genet 52, 642–643 (2020).

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