Fig. 1: cis-X workflow. | Nature Genetics

Fig. 1: cis-X workflow.

From: Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X

Fig. 1

cis-X was designed to perform integrated analysis of WGS and RNA-seq data generated from an individual tumor genome. It integrates ASE and outlier high expression as key signatures of cis-activated genes to seed the discovery of regulatory noncoding variants in the context of 3D architecture of the genome. Functional genomics data such as ChIP–seq generated from samples with matching tissue of origin and variant context can be provided by the user to enhance candidate variant annotation.

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