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DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways

TET2 and DNMT3A mutations lead to similar long-term outcomes in blood cancers despite the antagonistic biochemical functions of their encoded proteins. A new study highlights the opposing effects of TET2 and DNMT3A mutations in shaping the early erythroid or myeloid bias of hematopoietic progenitors.

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Fig. 1: DNMT3A and TET2 mutations lead to divergent differentiation biases through opposing changes in DNA methylation at TF-binding sites.


  1. 1.

    Bestor, T. H., Edwards, J. R. & Boulard, M. Proc. Natl Acad. Sci. USA 112, 6796–6799 (2015).

    CAS  Article  Google Scholar 

  2. 2.

    Sperling, A. S., Gibson, C. J. & Ebert, B. L. Nat. Rev. Cancer 17, 5–19 (2017).

    CAS  Article  Google Scholar 

  3. 3.

    Jaiswal, S. & Libby, P. Nat. Rev. Cardiol. 17, 137–144 (2020).

    Article  Google Scholar 

  4. 4.

    Izzo, F. et al. Nat. Genet. 52, 378–387 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Pronier, E. et al. Blood 118, 2551–2555 (2011).

    CAS  Article  Google Scholar 

  6. 6.

    Moran-Crusio, K. et al. Cancer Cell 20, 11–24 (2011).

    CAS  Article  Google Scholar 

  7. 7.

    Rasmussen, K. D. et al. Genes Dev. 29, 910–922 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    López-Moyado, I. F. et al. Proc. Natl Acad. Sci. USA 116, 16933–16942 (2019).

    Article  Google Scholar 

  9. 9.

    Yin, Y. et al. Science 356, eaaj2239 (2017).

    Article  Google Scholar 

  10. 10.

    Kaya-Okur, H. S. et al. Nat. Commun. 10, 1930 (2019).

    Article  Google Scholar 

  11. 11.

    Zhang, X. et al. Nat. Genet. 48, 1014–1023 (2016).

    CAS  Article  Google Scholar 

  12. 12.

    Barnett, K. R. et al. Mol. Cell 77, 1350–1364.e6 (2020).

    CAS  Article  Google Scholar 

  13. 13.

    Guryanova, O. A. et al. Leukemia 30, 1133–1142 (2016).

    CAS  Article  Google Scholar 

  14. 14.

    Quivoron, C. et al. Cancer Cell 20, 25–38 (2011).

    CAS  Article  Google Scholar 

  15. 15.

    Meisel, M. et al. Nature 557, 580–584 (2018).

    CAS  Article  Google Scholar 

  16. 16.

    Ostrander, E. L. et al. Stem Cell Rep. 14, 551–560 (2020).

    CAS  Article  Google Scholar 

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Correspondence to Anjana Rao.

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López-Moyado, I.F., Rao, A. DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways. Nat Genet 52, 554–556 (2020).

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