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EPIGENOMICS

DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways

TET2 and DNMT3A mutations lead to similar long-term outcomes in blood cancers despite the antagonistic biochemical functions of their encoded proteins. A new study highlights the opposing effects of TET2 and DNMT3A mutations in shaping the early erythroid or myeloid bias of hematopoietic progenitors.

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Fig. 1: DNMT3A and TET2 mutations lead to divergent differentiation biases through opposing changes in DNA methylation at TF-binding sites.

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Correspondence to Anjana Rao.

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López-Moyado, I.F., Rao, A. DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways. Nat Genet 52, 554–556 (2020). https://doi.org/10.1038/s41588-020-0641-2

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