Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CANCER EVOLUTION

Springing an evolutionary trap on cancer

Nature Genetics volume 52, pages 361–362 (2020)Cite this article

Subjects

Cancer cells have the extraordinary evolutionary potential to adapt and acquire resistance to most conventional and targeted therapies. In a new study, Lin et al., develop a systematic approach to identify combination therapies that produce cancer traps, in which evading the first drug makes the cancer vulnerable to the second.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Examples and strategies to overcome therapy resistance in cancer.

References

  1. Arnold, M. et al. Lancet Oncol. 20, 1493–1505 (2019).

    Article  Google Scholar 

  2. Lin, K. H. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0590-9 (2020).

  3. Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M. & Sorger, P. K. Nature 459, 428–432 (2009).

    Article  CAS  Google Scholar 

  4. Baguley, B. C. Mol. Biotechnol. 46, 308–316 (2010).

    Article  CAS  Google Scholar 

  5. Cortes, J. E. et al. N. Engl. J. Med. 367, 2075–2088 (2012).

    Article  CAS  Google Scholar 

  6. Wylie, A. A. et al. Nature 543, 733–737 (2017).

    Article  CAS  Google Scholar 

  7. Chen, C. D. et al. Nat. Med. 10, 33–39 (2004).

    Article  CAS  Google Scholar 

  8. Easwaran, H., Tsai, H. C. & Baylin, S. B. Mol. Cell 54, 716–727 (2014).

    Article  CAS  Google Scholar 

  9. Shu, S. et al. Nature 529, 413–417 (2016).

    Article  CAS  Google Scholar 

  10. van Groningen, T. et al. Nat. Genet. 49, 1261–1266 (2017).

    Article  CAS  Google Scholar 

  11. Alqahtani, A. et al. Future Sci. OA 5, FSO372 (2019).

    Article  CAS  Google Scholar 

  12. Hovestadt, V. et al. Nature 572, 74–79 (2019).

    Article  CAS  Google Scholar 

  13. Neftel, C. et al. Cell 178, 835–849.e821 (2019).

    Article  CAS  Google Scholar 

  14. Yu, C. et al. Nat. Biotechnol. 34, 419–423 (2016).

    Article  CAS  Google Scholar 

  15. Tsherniak, A. et al. Cell 170, 564–576.e516 (2017).

    Article  CAS  Google Scholar 

  16. Cowling, V. H. & Cole, M. D. Oncogene 27, 1327–1332 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kronos Bio, Cambridge, MA, USA

    Charles Y. Lin

  2. Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, USA

    Charles Y. Lin

Authors
  1. Charles Y. Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Charles Y. Lin.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lin, C.Y. Springing an evolutionary trap on cancer. Nat Genet 52, 361–362 (2020). https://doi.org/10.1038/s41588-020-0608-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-020-0608-3

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer