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FUNCTIONAL GENOMICS

Silencers in the spotlight

Efforts to systematically characterize silencers in animal genomes have been limited. Two studies in this issue of Nature Genetics bring silencers into the spotlight, identifying these elements genome wide in human and mouse cells, and providing insights into their function.

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Fig. 1: Transcriptional silencers in animal genomes.

References

  1. 1.

    Sawada, S., Scarborough, J. D., Killeen, N. & Littman, D. R. Cell 77, 917–929 (1994).

    CAS  Article  Google Scholar 

  2. 2.

    Siu, G., Wurster, A. L., Duncan, D. D., Soliman, T. M. & Hedrick, S. M. EMBO J. 13, 3570–3579 (1994).

    CAS  Article  Google Scholar 

  3. 3.

    Pang, B. & Snyder, M. P. Nat. Genet. https://doi.org/10.1038/s41588-020-0578-5 (2020).

  4. 4.

    Beck, D. B., Oda, H., Shen, S. S. & Reinberg, D. Genes Dev. 26, 325–337 (2012).

    CAS  Article  Google Scholar 

  5. 5.

    Freire-Pritchett, P. et al. eLife 6, e21926 (2017).

    Article  Google Scholar 

  6. 6.

    Schoenfelder, S. et al. Nat. Genet. 47, 1179–1186 (2015).

    CAS  Article  Google Scholar 

  7. 7.

    Cruz-Molina, S. et al. Cell Stem Cell 20, 689–705.e9 (2017).

    CAS  Article  Google Scholar 

  8. 8.

    Ngan, C. Y. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0581-x (2020).

  9. 9.

    Gisselbrecht, S. S. et al. Mol. Cell 77, 324–337.e8 (2020).

    Article  Google Scholar 

  10. 10.

    Azuara, V. et al. Nat. Cell Biol. 8, 532–538 (2006).

    CAS  Article  Google Scholar 

  11. 11.

    Bernstein, B. E. et al. Cell 125, 315–326 (2006).

    CAS  Article  Google Scholar 

  12. 12.

    Rada-Iglesias, A. et al. Nature 470, 279–283 (2011).

    CAS  Article  Google Scholar 

  13. 13.

    Galupa, R. et al. Mol. Cell 77, 352–367.e8 (2020).

    Article  Google Scholar 

  14. 14.

    Benabdallah, N. S. et al. Mol. Cell 76, 473–484.e7 (2019).

    CAS  Article  Google Scholar 

  15. 15.

    Alexander, J. M. et al. eLife 8, e41769 (2019).

    Article  Google Scholar 

Download references

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Correspondence to Mikhail Spivakov.

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Della Rosa, M., Spivakov, M. Silencers in the spotlight. Nat Genet 52, 244–245 (2020). https://doi.org/10.1038/s41588-020-0583-8

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