RNA:DNA HYBRIDS

m6A RNA modification as a new player in R-loop regulation

RNA:DNA hybrids that form across genomes control a wide range of biological processes. A new study shows that N6-methyladenosine (m6A) modification on the RNA moieties regulates the formation and genome integrity of these hybrids. This finding opens a new avenue of research on how RNA modifications (the ‘epitranscriptome’) can help control genome maintenance.

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Fig. 1: Expanding the functions of the m6A RNA pathway.

Change history

  • 20 January 2020

    In the version of the article originally published, the subject preceding the title contained placeholder text rather than the correct ‘RNA:DNA hybrids’. The error has been corrected in the HTML and PDF versions of the article.

References

  1. 1.

    Crossley, M. P., Bocek, M. & Cimprich, K. A. Mol. Cell 73, 398–411 (2019).

  2. 2.

    García-Muse, T. & Aguilera, A. Cell 179, 604–618 (2019).

  3. 3.

    Puget, N., Miller, K. M. & Legube, G. DNA Repair (Amst.) 81, 102661 (2019).

  4. 4.

    Abakir, A. et al. Nat. Genet. https://doi.org/10.1038/s41588-019-0549-x (2020).

  5. 5.

    Shi, H., Wei, J. & He, C. Mol. Cell 74, 640–650 (2019).

  6. 6.

    Xiang, Y. et al. Nature 543, 573–576 (2017).

  7. 7.

    Li, J. et al. Cell Biosci. 9, 66 (2019).

  8. 8.

    Wu, F. et al. Virol. J. 16, 133 (2019).

  9. 9.

    Yang, X. et al. Cell Res. 29, 1035–1038 (2019).

  10. 10.

    Park, O. H. et al. Mol. Cell 74, 494–507.e8 (2019).

  11. 11.

    Molla-Herman, A., Vallés, A. M., Ganem-Elbaz, C., Antoniewski, C. & Huynh, J. R. EMBO J. 34, 3009–3027 (2015).

  12. 12.

    Kotsantis, P. et al. Nat. Commun. 7, 13087 (2016).

  13. 13.

    Huang, Y. et al. Cancer Cell 35, 677–691.e10 (2019).

  14. 14.

    Stolz, R. et al. Proc. Natl Acad. Sci. USA 116, 6260–6269 (2019).

  15. 15.

    Cohen, S. et al. Nat. Commun. 9, 533 (2018).

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Correspondence to Gaëlle Legube.

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Marnef, A., Legube, G. m6A RNA modification as a new player in R-loop regulation. Nat Genet 52, 27–28 (2020). https://doi.org/10.1038/s41588-019-0563-z

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