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m6A RNA modification as a new player in R-loop regulation

This article has been updated

RNA:DNA hybrids that form across genomes control a wide range of biological processes. A new study shows that N6-methyladenosine (m6A) modification on the RNA moieties regulates the formation and genome integrity of these hybrids. This finding opens a new avenue of research on how RNA modifications (the ‘epitranscriptome’) can help control genome maintenance.

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Fig. 1: Expanding the functions of the m6A RNA pathway.

Change history

  • 20 January 2020

    In the version of the article originally published, the subject preceding the title contained placeholder text rather than the correct ‘RNA:DNA hybrids’. The error has been corrected in the HTML and PDF versions of the article.


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Correspondence to Gaëlle Legube.

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Marnef, A., Legube, G. m6A RNA modification as a new player in R-loop regulation. Nat Genet 52, 27–28 (2020).

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