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RNA:DNA HYBRIDS

m6A RNA modification as a new player in R-loop regulation

Nature Genetics volume 52, pages27–28(2020)Cite this article

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This article has been updated

RNA:DNA hybrids that form across genomes control a wide range of biological processes. A new study shows that N6-methyladenosine (m6A) modification on the RNA moieties regulates the formation and genome integrity of these hybrids. This finding opens a new avenue of research on how RNA modifications (the ‘epitranscriptome’) can help control genome maintenance.

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Fig. 1: Expanding the functions of the m6A RNA pathway.

Change history

  • 20 January 2020

    In the version of the article originally published, the subject preceding the title contained placeholder text rather than the correct ‘RNA:DNA hybrids’. The error has been corrected in the HTML and PDF versions of the article.

References

  1. 1.

    Crossley, M. P., Bocek, M. & Cimprich, K. A. Mol. Cell 73, 398–411 (2019).

    CAS  Article  Google Scholar 

  2. 2.

    García-Muse, T. & Aguilera, A. Cell 179, 604–618 (2019).

    Article  Google Scholar 

  3. 3.

    Puget, N., Miller, K. M. & Legube, G. DNA Repair (Amst.) 81, 102661 (2019).

    Article  Google Scholar 

  4. 4.

    Abakir, A. et al. Nat. Genet. https://doi.org/10.1038/s41588-019-0549-x (2020).

    Article  Google Scholar 

  5. 5.

    Shi, H., Wei, J. & He, C. Mol. Cell 74, 640–650 (2019).

    CAS  Article  Google Scholar 

  6. 6.

    Xiang, Y. et al. Nature 543, 573–576 (2017).

    CAS  Article  Google Scholar 

  7. 7.

    Li, J. et al. Cell Biosci. 9, 66 (2019).

    Article  Google Scholar 

  8. 8.

    Wu, F. et al. Virol. J. 16, 133 (2019).

    Article  Google Scholar 

  9. 9.

    Yang, X. et al. Cell Res. 29, 1035–1038 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Park, O. H. et al. Mol. Cell 74, 494–507.e8 (2019).

    CAS  Article  Google Scholar 

  11. 11.

    Molla-Herman, A., Vallés, A. M., Ganem-Elbaz, C., Antoniewski, C. & Huynh, J. R. EMBO J. 34, 3009–3027 (2015).

    CAS  Article  Google Scholar 

  12. 12.

    Kotsantis, P. et al. Nat. Commun. 7, 13087 (2016).

    CAS  Article  Google Scholar 

  13. 13.

    Huang, Y. et al. Cancer Cell 35, 677–691.e10 (2019).

    CAS  Article  Google Scholar 

  14. 14.

    Stolz, R. et al. Proc. Natl Acad. Sci. USA 116, 6260–6269 (2019).

    CAS  Article  Google Scholar 

  15. 15.

    Cohen, S. et al. Nat. Commun. 9, 533 (2018).

    Article  Google Scholar 

Download references

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Affiliations

  1. LBCMCP, Centre de Biologie Intégrative (CBI), CNRS, Université de Toulouse, Toulouse, France

    Aline Marnef & Gaëlle Legube

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  1. Aline Marnef
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  2. Gaëlle Legube
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Correspondence to Gaëlle Legube.

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The authors declare no competing interests.

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Marnef, A., Legube, G. m6A RNA modification as a new player in R-loop regulation. Nat Genet 52, 27–28 (2020). https://doi.org/10.1038/s41588-019-0563-z

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