Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

RNA:DNA HYBRIDS

m6A RNA modification as a new player in R-loop regulation

This article has been updated

RNA:DNA hybrids that form across genomes control a wide range of biological processes. A new study shows that N6-methyladenosine (m6A) modification on the RNA moieties regulates the formation and genome integrity of these hybrids. This finding opens a new avenue of research on how RNA modifications (the ‘epitranscriptome’) can help control genome maintenance.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Expanding the functions of the m6A RNA pathway.

Change history

  • 20 January 2020

    In the version of the article originally published, the subject preceding the title contained placeholder text rather than the correct ‘RNA:DNA hybrids’. The error has been corrected in the HTML and PDF versions of the article.

References

  1. Crossley, M. P., Bocek, M. & Cimprich, K. A. Mol. Cell 73, 398–411 (2019).

    Article  CAS  Google Scholar 

  2. García-Muse, T. & Aguilera, A. Cell 179, 604–618 (2019).

    Article  Google Scholar 

  3. Puget, N., Miller, K. M. & Legube, G. DNA Repair (Amst.) 81, 102661 (2019).

    Article  Google Scholar 

  4. Abakir, A. et al. Nat. Genet. https://doi.org/10.1038/s41588-019-0549-x (2020).

    Article  Google Scholar 

  5. Shi, H., Wei, J. & He, C. Mol. Cell 74, 640–650 (2019).

    Article  CAS  Google Scholar 

  6. Xiang, Y. et al. Nature 543, 573–576 (2017).

    Article  CAS  Google Scholar 

  7. Li, J. et al. Cell Biosci. 9, 66 (2019).

    Article  Google Scholar 

  8. Wu, F. et al. Virol. J. 16, 133 (2019).

    Article  Google Scholar 

  9. Yang, X. et al. Cell Res. 29, 1035–1038 (2019).

    Article  CAS  Google Scholar 

  10. Park, O. H. et al. Mol. Cell 74, 494–507.e8 (2019).

    Article  CAS  Google Scholar 

  11. Molla-Herman, A., Vallés, A. M., Ganem-Elbaz, C., Antoniewski, C. & Huynh, J. R. EMBO J. 34, 3009–3027 (2015).

    Article  CAS  Google Scholar 

  12. Kotsantis, P. et al. Nat. Commun. 7, 13087 (2016).

    Article  CAS  Google Scholar 

  13. Huang, Y. et al. Cancer Cell 35, 677–691.e10 (2019).

    Article  CAS  Google Scholar 

  14. Stolz, R. et al. Proc. Natl Acad. Sci. USA 116, 6260–6269 (2019).

    Article  CAS  Google Scholar 

  15. Cohen, S. et al. Nat. Commun. 9, 533 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gaëlle Legube.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Marnef, A., Legube, G. m6A RNA modification as a new player in R-loop regulation. Nat Genet 52, 27–28 (2020). https://doi.org/10.1038/s41588-019-0563-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-019-0563-z

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing