Number of genus hits among tumor samples for the three independent pipelines and the consensus set defined by evidence from multiple pipelines. a, Analysis based on WGS. b, Analysis based on whole-transcriptome sequencing. c, Heat map showing the total number of viruses detected across various cancer entities. The sequencing data used for detection are indicated among the total number of hits (WGS, blue; RNA sequencing, green). The fraction of virus-positive samples is shown at the top and the type of non-malignant tissue used in the analysis is indicated if more than 15% of the analyzed samples are from a respective tissue type (solid tissue, lymph node, blood or adjacent to primary tumor). d, t-SNE clustering of the tumor samples based on PMER of their consensus virome profiles, using Pearson correlation as the distance metric. Major clusters are highlighted by indicating the strongest viral genus and the dominant tissue types that are positive in that cluster. Dot size represents the viral reads PMER.