EPITRANSCRIPTOMICS

NPM1 functions in epitranscriptomics

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A new study identifies germline NPM1 mutations in people with dyskeratosis congenita. These NPM1 mutations inhibit ribosomal RNA 2´-O-methylation by decreasing the binding of the rRNA methyltransferase FBL to small nucleolar RNAs. Thus, NPM1 influences ribosomal functions via epitranscriptomic regulation.

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Fig. 1: NPM1 functions as an rRNA 2´-O-Me regulator.

References

  1. 1.

    Piekna-Przybylska, D., Decatur, W. A. & Fournier, M. J. Nucleic Acids Res. 36, D178–D183 (2008).

  2. 2.

    Draptchinskaia, N. et al. Nat. Genet. 21, 169–175 (1999).

  3. 3.

    Ruggero, D. et al. Science 299, 259–262 (2003).

  4. 4.

    Schwartz, S. et al. Cell 159, 148–162 (2014).

  5. 5.

    Marcel, V. et al. Cancer Cell 24, 318–330 (2013).

  6. 6.

    Zhou, F. et al. Nat. Cell Biol. 19, 844–855 (2017).

  7. 7.

    Nachmani, D. et al. Nat. Genet. https://doi.org/10.1038/s41588-019-0502-z (2019).

  8. 8.

    Signer, R. A., Magee, J. A., Salic, A. & Morrison, S. J. Nature 509, 49–54 (2014).

  9. 9.

    Blanco, S. et al. Nature 534, 335–340 (2016).

  10. 10.

    Marchand, V., Blanloeil-Oillo, F., Helm, M. & Motorin, Y. Nucleic Acids Res. 44, e135 (2016).

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Correspondence to Carsten Müller-Tidow.

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