3D GENOMICS

Jumping retroviruses nudge TADs apart

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Far from being junk DNA, the pervasive retrotransposons that populate the genome have a powerful capacity to influence genes and chromatin. A new study demonstrates how the transcription of one such element, HERV-H, can modify the higher-order 3D structure of chromatin during early primate development.

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Fig. 1: Functionally co-opted ERVs have diverse activities.

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Correspondence to Stefan Mundlos.

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